|A part of the Phen – Fen anti obesity drug, phentermine is the commonly prescribed appetite suppressant, accounting for 50% of the prescriptions. The other part of Phen-Fen was Fenfluramine. It was withdrawn from the US market in 1997 because of its side effects like pulmonary hypertension and heart valve disease.
Phentermine work with neuro transmitters in the brain. It encourages neuron bundles to release a group of neuro transmitters called catecholamine. It includes dopamine, epinephrine and norepinephrine. They decrease hunger pangs in the body. Therefore, the brain doesn’t get the hunger message and you lose your appetite.
In 1959, Phentermine got approval from the Food and Drug Administration as an appetite suppressant for treating obesity. Phentermine resin came in for sale in US during this year where as Phentermine hydrochloride entered the market in 1970’s. Phentermine diet pills are sold under two brand names in the US, Ionamin and Adipex. It is also available in the form of a generic medication as Phentermine.
Formerly King Pharmaceuticals for SmithKline Beecham produced Phentermine. It was sold under the name Fastin. However, in 1998 Fastin vanished from the market because of its severe side effects.
The truth about Phen-Fen
The FDA didn’t approve it as there were studies showing side effects as severe as primary pulmonary hypertension and heart valve problems. Though Phen – Fen emerged as a successful combination and people prescribed it, they stayed out of it as soon as the FDA cautioned them of its side effects. Soon, FDA banned Fenfluramine. But Phentermine was still available for use.
The new Phen-Pro cocktail